A number of reptiles and amphibians occur in the Marico BR area.  

In terms of the reptiles, 46 species have been listed within the Marico BR area. Of the reptiles, one- the Nile crocodile, Crocodylus niloticus, which occurs marginally- is classified as Vulnerable. Both the Nile crocodile and the Southern African python, Python natalensis, are Protected species according to the National TOPS legislation. There are three Near endemics, the Common Girdled Lizard (Cordylus vittifer), the Southern Rock Agama (Agama atra) and Bibron's Blind Snake (Afrotyphlops bibronii) as well as one South African endemic, the Eastern Ground Agama (Agama aculeata distanti) that occur in the BR area. The Eastern Ground Agama occurs on the Highveld grasslands.

In terms of the amphibians, 15 species have been listed within the Marico BR area of which only two bullfrog species are suspected Protected species as far as the TOPS national legislation.